The big downside to Strinati's (and by extension the Glass cannon) is you only get 2 hits of damage (vs. 4 for toven's and 5 for corruption/archaic). My recollection of strinati's was that mobs didn't save vs. force but did vs. fire, and that the two damage types were affected separately by fire / force enhancements. Also, just as reflex saves and evasion are an issue for Toven's, the same will apply to the Glass cannon.
What will be interesting is to compare how Glass cannon does vs Toven's against evasion mobs. My suspicion is that new runearms may be created with hidden boosts to DC (I can't imagine them staying relevant vs. inflated mob saves otherwise). If we don't see any evidence of this, despite higher mob saves in eGH, I think its fair to say that reflex based runearms are essentially dead for the highest difficulty levels.
I too was hopeful about the Glass cannon, but am very doubtful having seen some of the comments from Lammania. It will still function as a bigger better crate and door smasher however...