I mean, what is a 64-bit server compared to 32-bit in a game like DDO? Seems to me all that could possibly mean is double the connection bandwidth unless it's simply a way to say you're making one server that you will ensure works better than the others. And/or is it the first step to shutting down 32-bit servers and hence making DDO a paid-only game?
SSG's server has a thingy (they don't name it) that is responsible for server-side code. With 32-bit it's restricted to 3 GB with a paging system to load code and data in and out of memory. Back in the day when the game wasn't that complex it rarely if ever occurred but as the game has become more complex the rate of paging has increased to the point where it now thrashes frequently. This is often seen as a massive lag spike freezing everyone in place.
Since 64-bit can address up to 18 EB (18,446,744,073 GB) the paging restriction is pushed to as much memory as is available on the server. Servers with up to 2 TB (2,000 GB) are very common these days if a bit expensive. That's 667 times the available memory meaning you would need server-side code and data to grow to 667 times the size to hit the complexity again.
Word from the developers is that it's massively benefited LOTRO where this upgrade has already been implemented and rolled out.