Of my various lives:
Monk/DL/SF - Current life on my main, getting Sacred Fist past lives and using Trailblazer as I need those lives too but already have my regular Monk lives. Stick fighter, it's been a blast, using Dragon Lord for extra crit multiplier, wings, displacement, and roar. Not optimal, but it's been fun.
Monk stick - Frequently used for racial lives, basic stick build post Monk changes. Probably going to try out DL/Henshin next racial life set.
Bard/Barbarian/Else - Essentially Critzilla builds, SWF Kukri going up VKF and Ravager plus a bit into Swash. I've adapted it for a Bard life, Druid life (didn't feel like running a caster), and a few others. Mostly not optimal; I think the best version is the Shadar Kai life, but melts through most content. Occasionally I'd run DL, which is technically better, but I love my Barbarian run speed. I prefer adapting it to Iconics however, because it's such a deep multiclass the early levels are sucky.
Alchemist - Pure nuker, Cold in later levels but I did switch to Acid for the easiest run through Let Sleeping Dust Lie in memory. Falls off in Legendary, but good enough through epics/legendaries. I've basically used the same build for my guild run this life around, except corpse drunk and not whatever race I picked last time. Also a build I'll use for racial lives.
Druid - Cold caster, I didn't run it in epics much less legendary, but it was fun.
Exploiter Ranger - Classic old school build, Rogue 1/Fighter 1/Ranger 18. Basically could do everything to a degree. Now you get the same with Evil Ranger, which I've also enjoyed and ran a couple times. I have never ran a Ranger that was actually ranged.
Bitey Wolf Barbarian mess - Old build that was stuck on an alt that was retired for a long while. I lost the build sheet for it, but it was some hybrid of Winter Wolf, Barbarian, and Fighter. Old enough that Blight Caster didn't exist. Eventually I plan on figuring it out and modifying it for Blightcaster lives on my main.
FvS AA - Oddly mentioned by Tarrasque above, though it was half melted wax creature AA and not elf AA so the paralyzing effect was probably from the mobs looking at it in horror. Used in guild runs, very much fun and able to lock down everything with CC and keep the party alive during boss fights. Probably wouldn't run solo, mostly because I don't really care much for ranged gameplay.
Warlock - While not really great at higher levels, I have enjoyed my various Warlock lives here and there.
Disciple of the Pointy Stick - Pure Barbarian, Ravager, eSoS. Quick Cutter go Brrrrr. Also a build I have no problem cycling in for racial lives.