Enemies of different types have different strong and weak saves. Some have low will saves, some have low fort saves, some have low reflex saves. The goal for many is to get the DCs of their favorite spell up to always work even vs enemies with strong saves of that type, but if you are able you can have more than one CC spell, one for each target save. Web for reflex, mass hold for will, soundburst for fort, as an example. Then you can cast the appropriate spell to lock down your enemies and be able to do so with a wee bit more success... at least until you are able to get your DCs to 110+
(I was in a few R10 runs recently with only 100-105 on my DCs but was able to efficiently CC non-bosses just fine by targeting weak saves. Though this was in Cerulean hills, ravenloft, and saltmarsh)
edit: some champions were harder to lock down than others. sometimes one was able to break free and made for some intense moments.