Here is what I mainly run (sometimes I add in deviations for the novelty).
Assuming 30%/50% pot, often duo, sometimes solo leading whatever pugs join.
Preferably some xp stones but I am running out..
Harbour (Ringleader REHN, others just R, skipping some, doing most)
Waterworks (skip 4th if solo)
Take level 5
3bc (FC1 REHN (really fast duo, still fast solo), Ghost REH duo as optionals are that good or just R if solo, most other R)
4 short House K quests mostly for the favor
Delaras 1
Take level 8
Delaras 2-4, Tear, Gwylands, Some/most of Isle of D
Spies
Von1-4
WPM
SC REHN (have opener on 2nd account)
Take level 12
TS (shortcut)
Ravenloft
Sands (not chains, not adq)
Dead Shall Rise
Relic
Diplo chain
Take level 15
GH (sans crucible)
Grim, Sub, Multi
Necro 4
Litany
Take 17
Missing (sometimes chain, sometimes just missing)
Sharn 1
Cogs
Take 18
Sharn 2
If not 20 add a few more
Sane Asylum, Members Only (w bluff), Wheloon
Much has to do with running quests that are objectively fast, but much also has to do with running quests you know well
Comments and ideas are most welcome